I've done a bit of reading up and have noted:
-the FTDI USB chip will not be on the board drawing power. I can program the ESP through a connector when needed.
-GPIO16 has to be connected to Reset
My question has to do with pullup resistors on the i2c lines needed for the temp/humid sensor. Wouldn't two 10K resistors on SDA and SCL to +3.3V constantly draw power?